Ukubunjwa kwazo zonke iiseli zomzimba kubandakanya ama-esters ama-acids aphezulu kunye ne-alcohols. Ezi zixhobo zeekhemikhali zibizwa ngokuba yi-phospholipids, zinoxanduva lokugcina isakhiwo esifanelekileyo seengxube, ukuthatha inxaxheba kwiinkqubo ze-metabolic and in the cleavage ye-cholesterol. Isimo sempilo jikelele sixhomekeke ekugxininiseni kwezi zinto.
I-AFS-syndrome - yintoni na?
Phantse kwiminyaka engama-35 edlulileyo, i-rheumatologist uGraham Hughes ufumene i-pathology apho i-immune system iqala ukuvelisa i-antibodies ethile malunga ne-phospholipids. Badibanisa kwiiplatelet kunye neendonga ze-vascular, zisebenzelana namaprotheni, zingene kwiimpendulo zokuxilonga kunye nokuqhawula. Bobabini isifo sesibini kunye nesisiseko se-antiphospholipid antibodies sisifo esingazimela ngokungaqhelekanga. Le ngxaki inokuchaphazela abafazi abancinci bexesha lokuzala.
Antiphospholipid syndrome - izizathu
Ku-rheumatologist kodwa kwakungenakwenzeka ukuseka, kutheni kukho ukugula okanye isifo. Kukho ulwazi lokuba isifo se-antiphospholipid sisifo esivame ukufunyaniswa kwizihlobo ezinesifo esifanayo. Ukongeza kwindlalifa, iingcali zibonisa ezinye izinto ezinokubangela ukugula. Kwiimeko ezinjalo, i-AFS yesibini ikhula-izizathu zokuveliswa kwe-antibody ziquka ukuqhubela kwezinye izifo ezichaphazela ukusebenza komzimba womzimba. Isicwangciso sonyango luxhomekeke kwiindlela zokuqala kwesi sifo.
I-antiphospholipid syndrome
Olu hlobo lwesifo lukhula ngokuzimeleyo, kwaye aluhambisani nemvelaphi yeengxaki ezithile emzimbeni. Le ngxaki ye-antiphospholipid antibodies kunzima ukuyiphatha ngenxa yokungabikho kwemibandela echukumisayo. Ngokuqhelekileyo uhlobo oluphambili lwesifo luyinto engabonakaliyo kwaye ifunyenwe kakade kwiimigangatho ezithe gqolo zokuqhubela phambili okanye xa kuthe kwenzeka iingxaki.
I-antiphospholipid syndrome yesibini
Olu hlobo lokuphendula ngokuzenzekelayo luvela ngenxa yobukho bezinye izifo zenkqubo okanye ezinye iziganeko zeklinikhi. Impembelelo ekuqalekeni kokuphuhliswa kweentsholongwane yamathambo angakwazi ukukhulelwa. I-Antiphospholipid syndrome kubasetyhini abakhulelweyo ifunyanwa kwi-5% yamatyala. Ukuba isifo esikulo mbuzo sifunyenwe ngaphambili, ukunyamezela kuya kunzima kakhulu.
Izifo ezinokuthi zenza i-antiphospholipid syndrome:
- ukusuleleka kwintsholongwane kunye neentsholongwane;
- neoplasms;
- periarteritis;
- lupus erythematosus.
Antifospholipid syndrome - iimpawu kubasetyhini
Umfanekiso weklinikhi we-pathology uhlukene kakhulu kwaye awunamkhethe, obandakanya ukuxilongwa ngokuhlukileyo. Ngamanye amaxesha i-disorder iyenzeka ngaphandle kwempawu, kodwa i-antiphospholipid syndrome ibonakala ngokuphindaphindiweyo nge-thrombosis yentsholongwane engaphelelekanga kunye negazi (imirhoxo okanye imivini):
- izitho ezisezantsi;
- isibindi;
- retina;
- ingqondo;
- ntliziyo;
- kukhanya;
- izintso.
Izimpawu eziqhelekileyo kwabasetyhini:
- umzekelo we-vascular pattern kwesikhumba (i-liveroid).
- i-myocardial infarction;
- migraines;
- ukuxhatshazwa;
- intlungu esifuba;
- imilenze ye-varicose;
- thrombophlebitis;
- ukubetha;
- ngxinzelelo lwegazi;
- ukungakwazi ukuphelelwa ngumlomo;
- phezulu;
- ukuhlaselwa
- ukukhwehlela okunzima;
- i-necrosis yamathambo kunye nama-soft tissue;
- ukuxinzeleleka kwegazi;
- ukuphuma kwamanzi;
- umonakalo omkhulu wesibindi;
- i-spleen infarction;
- ukufa komntwana kwangaphakathi;
- ukukhulelwa komzimba.
Antifospholipid syndrome - ukuxilongwa
Kunzima ukuqinisekisa ubungqina be-pathology echazwe, kuba i-masks kwezinye izifo, inezibonakaliso ezingenasiphelo. Ukuxilonga isifo, oogqirha basebenzisa ii-2 zeendlela zokukhetha. Uviwo lwe-antiphospholipid syndrome kuqala lubandakanya ukuqokelela i-anamnesis. Uhlobo lokuqala loqhotyoshelweyo luquka iziganeko zekliniki:
- I-vascular thrombosis. Imbali yonyango kufuneka ibe neyodwa okanye eminye imiba yomonakalo kwiimvini okanye kwimithambo emiselweyo i-instrumental kunye nebhubhoratri.
- Ukukhubazeka kwempilo. Umqathango uthathelwa ingqalelo ukuba ukufa komntwana kwangaphakathi emva kokuphela kweveki ye-10 yesisu okanye ukuzalwa kwangaphambi kokuzalwa kwangaphambi kweeveki ezingama-34 zesigxina ngokungabikho kwe-chromosomal, i-hormonal kunye ne-anatomical defects evela kubazali.
Emva kokuba imbali yonyango iqokelelwa, ugqirha ukhetha izifundo ezongezelelweyo. I-Antiphospholipid syndrome iyaqinisekiswa xa kukho ukudibanisa uphawu olulodwa lwekliniki kunye ne-laboratory criterion (ubuncinci). Ngendlela efanayo, uninzi lweendlela zokuxilonga ezahlukeneyo zenziwa. Ngenxa yoko, uphando luyacetyisa ukuba ufunde iimviwo ezingafaki izifo ezifanayo.
Uhlalutyo lwe-Antiphospholipid syndrome
Ukufunyanwa kweempawu zebhubhoratri zengxaki yesimo esilungelelaniswa nokufundwa kwamanzi e-biological. Ugqirha ukhetha ukunikela ngegazi kwi-antiphospholipid syndrome ukucacisa ubukho be-plasma ne-serum antibodies kwi-cardiolipins kunye ne-lupus anticoagulant. Ukongezelela, oku kulandelayo kungabonwa:
- i cryoglobulins;
- amachiza e-erythrocytes;
- I-T- kunye ne-B-lymphocyte ekuxininiseni okwandisiweyo;
- isunyukliya kunye ne-rheumatoid factor.
Ngamanye amaxesha ukucetyiswa kofuzo kukuvumela ukuba ufumane amanqaku e-antiphospholipid syndrome:
- HLA-DR7;
- HLA-B8;
- HLA-DR2;
- DR3-HLA.
I-antiphospholipid syndrome iphathwa njani?
Ulwaphulo lwezifo ezizimeleyo luxhomekeke kwimo (kwiprayimari, isibini) kunye nobunzima beempawu zeklinikhi. Iingxaki zivela xa owesifazane okhulelwe ene-antiphospholipid syndrome - unyango kufuneka luyimpembelelo yempawu zesifo, ukuthintela i-thrombosis, kwaye ngokufanayo akuyi kuba yingozi kumntwana. Ukufikelela ekuphuculeni okuqhubekayo, i-rheumatologists isebenzisa indlela yokwelapha edibeneyo.
Ngaba kunokwenzeka ukuphilisa i-antiphospholipid syndrome?
Ukuphelisa ngokupheleleyo ingxaki echazweyo akunakwenzeka, de kubekho izizathu zokuvela kwayo. I-Antiphospholipid syndrome idinga unyango olunzima olujoliswe ekunciphiseni inani le-antibodies efanelekileyo egazini kunye nokukhusela iingxaki ze-thromboembolic. Kwimeko enzima yesi sifo, unyango oluchasayo luyafuneka.
Unyango lwe-antiphospholipid syndrome - iingcebiso zangoku
Indlela eyona nto yokuphelisa impawu zale ntsholongwane kukusetyenziswa kwamagagagregregants and antiticoagulants of action ngqo:
- I-Acetylsalicylic acid (i-Aspirin kunye neempawu ezifanayo);
- Warfarin ;
- Acenocoumarol;
- Phenylin;
- I-Dipyridamole.
Indlela yokuphatha i-antiphospholipid syndrome - iingcebiso zekliniki:
- Ukuyeka ukutshaya, ukusela utywala kunye neziyobisi, ukukhulelwa komlomo.
- Ukulungisa ukutya ngokutya ukutya okunothambile kwi-vitamin K - itiye eluhlaza, isibindi, imifuno eluhlaza.
- Ukuphumla ngokugqibeleleyo, gcina ulawulo lwaloo mini.
Ukuba unyango oluqhelekileyo alusebenzi, umkhuba wokumisela amayeza angezelelweyo:
- aminoquinolines - Plaquenil, uDelagil;
- i-antiticoagulants - i- Clexan , i-Fraksiparin;
- glucocorticoids - Prednisolone , i-Methylprednisolone;
- i-inhibitors yeepletlet receptors - iTagren, Clopidogrel;
- i-heparinoids - i-Emeran, i-Sulodexide;
- i-cytostatics - i-Endoxane, isiCytoxan;
- i-immunoglobulins (ukulawulwa kwe-intravenous).
Iyeza lemveli kunye ne-antiphospholipid syndrome
Ayikho enye indlela efanelekileyo yokwenza unyango, ukhetho olulodwa kuphela ukutshintshwa kwe-acetylsalicylic acid kunye nezinto ezibonakalayo zendalo. I-Antiphospholipid syndrome ayikwazi ukunqunyulwa ngoncedo lweendlela zokupheka, kuba i-anticoagulants yemvelo inefuthe elibi kakhulu. Ngaphambi kokusebenzisa nayiphi na enye indlela kubalulekile ukubonisana ne-rheumatologist. Ingcali kuphela iya kunceda ukunciphisa i-antiphospholipid syndrome - iingcebiso zegqirha kufuneka zigcinwe ngokuthe ngqo.
Ita neendawo ze-aspirin
Izithako:- umgca owomileyo willow white - 1-2 tsp.
- amanzi abilayo - 180-220 ml.
Ukulungiselela, sebenzisa :
- Imveliso eluhlaza ihlambulule kwaye igaya.
- Brew willow bark ngamanzi abilayo, gxi ninisa imizuzu engama-20-25.
- Phuza isisombululo nje ngetiyi 3-4 izihlandlo ngosuku, unako ukunambitha ukuze unambitha.
I-Antiphospholipid syndrome - i-prognosis
Zonke izigulane ze-rheumatologist ezine-diagnostic ezifunyenweyo kufuneka zigcinwe ixesha elide kwaye zihlale zihlolwa. Ndingahlala ixesha elingakanani ne-antiphospholipid syndrome, kuxhomekeke kwimo yayo, ubunzima kunye nobukho beengxaki zokuxilongwa kwe-immunological. Ukuba i-APS ephambili eneempawu ezimodareyithwayo ifunyenwe, unyango olufanelekileyo ngexesha elifanelekileyo kunye nokunyango olukhuselekileyo lunceda ukuphepha iingxaki, ukuxelwa kweemeko kwiimeko ezinjalo kulungile.
Iimeko ezinzima kakhulu zidibanisa nesifo esibuzwayo kunye ne-lupus erythematosus, i-thrombocytopenia, i-persistent blood pressure kunye nezinye izifo. Kule meko, ngokuqhelekileyo ivelisa i-antiphospholipid syndrome (inhlekelele), ebonakalisa ukwanda kweempawu zekliniki kunye ne-thrombosis ephindaphindiweyo. Eminye imiphumo ingaphelisa ukufa.
Antifospholipid syndrome kunye nokukhulelwa
Ukuchazwa kwesifo yimbangela eqhelekileyo yokukhulelwa kwesisu, ngoko bonke oomama abazayo kufuneka bafumane ukuhlolwa kweprophylactic kwaye banikele igazi kwi-coagulogram. I-Antiphospholipid syndrome kwiimbambano ibhekwa njengento ebangela ukuba ukufa komntwana kunye nokuphuphuma komzimba, kodwa ukuba khona kwayo akuyiyo isigwebo. Ibhinqa elinokuxilongwa okunjalo liyakwazi ukuthwala nokuzala umntwana onempilo ukuba xa ekhulelwe uya kulandela zonke iingcebiso zegqirha kwaye athathe i-antigregregants.
Isicwangciso esifanayo sisetyenziselwa ukucwangciswa kweengcambu zokufakelwa. I-Antiphospholipid syndrome kunye ne-IVF zihambelana ngokuthe ngqo, kuphela eziza kufuneka ziqhube iindidi zezilwanyana ezingenasiphene. Ukusetyenziswa kwama-antiticoagulants kunye nama-antigregregants kuya kuqhubeka lonke ixesha lokubamba. Ukusebenza kolo hlobo lonyango luphantse kwi-100%.