MAO inhibitors

Ii-inhibitors ze-MAO zizinto eziphilayo ezisebenzayo ezibangela ukutshatyalaliswa kokunyuka kweentsholongwane zentliziyo. Ezi ziyobisi zijolise ekuphatheni izifo ezithile zesifo, ukudandatheka, i-narcolepsy kunye nesifo sikaParkinson .

Ii-inhibitors ze-MAO-zibachaphazela ntoni?

Ngeziphathamandla zabo zezolimo, ezi zi yobisi zihlukaniswe zibe ziindidi ezininzi:

1. Inhibitors ezingenakukhetha ezingenakukhethwa, ezifana nokubunjwa kwiiproniazides. Banciphisa inani lokuhlaselwa kwe-angina, kwaye kukhokelela umntu ngaphandle kokudandatheka.
2. Ezikhethiweyo ezikhethiweyo zijoliswe ekunciphiseni i-deamination ye-noradrenaline kunye ne-serotonin. Ezi zi yobisi zineempembelelo ezichasayo.
3. Iziyobisi ezikhethiweyo ezikhethiweyo zisetyenziselwa ukuphatha isifo sikaParkinson. Zibandakanyeke ngqo kwi-metabolism ye-catecholamines kunye ne-dopamine.

I-MAO inhibitors - uludwe lwezilwanyana

Izidakamizwa ezingenakukhethwa

1. Ipronizade. Iyeza eliseqela lama-antidepressants. Unesiphumo esicacileyo se-hepatotoxic - sonakalisa isibindi somntu.
2. Nialamide. Le yintsholongwane. Umgubo ococekileyo wombala omhlophe nge-yellow tinge. Ayinakunqunyulwa kakuhle emanzini, kwaye kutywala-ngakumbi nakakhulu. Iyeza linyanzelwe abantu abanesibindi, iinjongo, iingxaki zentliziyo. Kwakunqweneleka ukuba kusetshenziswe ngabantu abanokukhubazeka kwe-cerebral circulation.
3. Isocarboxazide. Ngokuqhelekileyo kusetyenziselwa ukuphatha uxinzelelo kunye neengxaki zengxaki. Njengezinye iimichiza iqela lingalimaza isibindi, iintso kunye nentliziyo.
4. Fenelzin. Kuthatyathwa ukuphucula imeko yonke. Inokusetyenziswa kakhulu njengengcinezelo.
5. Tranylcypromine. Eli liyeza lenzelwe ukujongana nokudakumba. Kucatshangelwa ukukhuthaza. Kwisigaba esisebenzayo, i-arhente idlula i-amphetamine. Ezinye izigulane zinokuxhomekeka kwifuthe elikhuthazayo.

Uluhlu lwezilwanyana ezikhethiweyo ezikhethiweyo-MAO inhibitors

1. EBethol. Kuthathwa njengengcinezelo. Unamanyathelo okulwa neengxaki zokuchasana. Isiphumo sokubakho kwe-phenamine sinikezelwa.
2. MacLobemide. Isisombululo esichaphazela ukuxhatshazwa kweengxaki. Ukubunjwa kwalo kufana nokufana ne-befol, kodwa kusekho ukuhluka kwimoyi ye-molecular. Ngexesha lokumkela, iimbumba ezinomileyo ezinomqolo, intlungu ekhanda, isicongconi, ukulala, okanye ukulandelelana. Kwezinye iziganeko ukutyunjwa, iingxaki zesisu, ukuphazamiseka kwemisipha kunye nokukhubazeka kwesikhashana kwimbonakalo kwakubonwa. Izigulane ezinexinzelelo lwe-bipolar zidla ngokuguquka kwesigaba kwi-mania.
3. Pyrazidol. Isenzo saso sifana ne-Inkazan neTetrindol. Liyilungu elisebenzayo kubantu abanokudandatheka. Unempembelelo. Uphucula imisebenzi yokuqonda. Iyabonakala phakathi kwabanye ngenxa yokuba kunokwenzeka ukulawula impembelelo kwinkqubo ye-nervous.
4. Inkazan. Kwakhona i-metralindol. Kuthathwa njengelungiso lokuqala. Isetyenziswe ekuphuhliseni i-schizophrenia, i-psychosis yomntu okanye ukunyangwa kwezifo zesifo seengqondo. Kuboniswe ukukhutshwa kwamandla kunye nokupasa, ukuphazamiseka, kunye neemeko ezinobungqina bokunyamekela. Ngokuqhelekileyo kusetyenziselwa ukuphatha imeko yokudandatheka kwizigulana ezinxilisayo.

Ziziphi iziyobisi ezichazwe njenge-OO inhibitors ezingenakuphikiswa?

1. Selegiline. Isilwayo, isenzo saso sichazwe kunyango lweSiginsinson nesifo se-syndromes, esibangelwa ukungabikho kwe-dopamine.
2. Razagilin. Eli liyeza lisizukulwana esitsha sonyango. Ilwa ne-Parkinsonism ephawulekayo, ngokukodwa kunye nokukhubazeka kwemisebenzi emancinci. Ngokuqhelekileyo kusetyenziswa namanye amachiza eqela.