I-Diuretics liqela lezilwanyana zamachiza ahlukeneyo, okwenza isenzo saso sijoliswe ekuphuculeni i-diuresis-ukwakheka kunye nokugqithisa umchamo. Ukwamukelwa kwabo kunceda ukunciphisa umkhuhlane kwizicubu kunye neentambo zomzimba zomzimba. Kulo qela lala mayeza e-loop diuretics ayahlukana, aneempembelelo ezinamandla.
Indlela yokwenza i-loop diuretics
Ezi ziyobisi zichaphazela i-Gengle loop, eyingxenye yombumba we-renal ngohlobo lwe-loop, ejoliswe kwiziko leentso. Umsebenzi oyintloko we-Gengle loop ukubuyiswa kwakhona kwamanzi kunye neengxaki. Inkqubo yesenzo seelop diuretic drugs isekelwe kwimiphumo emininzi:
- ukuphumla kwemisipha evulekileyo yemithambo yegazi;
- ukunyuka kwegazi lokunyuka kwegazi;
- ukuqiniswa kokuhlanjululwa kwe-glomerular;
- kuncipha kwi-activation reabsorption esebenzayo ye-sodium, i-chlorine kunye ne-i-potassium ions;
- ukuvimbela ukubuyiswa kwakhona kwe-magnesium.
Ukongezelela kwiipropati ze-diuretic, ezi zi yobisi zichaphazela ezinye iipameterhe ze-hemodynamic, ingakumbi xa zilawulwa ngaphakathi, kwaye zinciphisa umthamo we-extracellular fluid kwaye zichaphazela imisebenzi yokuphefumula.
Isenzo sezilwanyana zamathambo e-diuretic senzeke ngokukhawuleza (emva kwemizuzu engama-20 ukuya kwimizuzu engama-60) kwaye singaphelela kwiiyure ezingama-4 ukuya kwe-6. Ukusetyenziswa kwezi zixhobo kuboniswe kuphela kwiimeko ezibucayi. banemiphumo emibi kakhulu. Ngokukodwa, zisetyenziselwa:
- ntlekele ;
- i-edema yepommonari;
- i-edema yengqondo;
- ukungaphumeleli kwindlala;
- ukuhluleka kwentliziyo;
- i-cirrhosis yesibindi;
- hypercalcemia .
Uludwe lwe-diuretics
Kuluhlu lwe-loop diuretics zilungiselelwe ngokusekelwe kwezi zinto zilandelayo:
- furosemide;
- turosemide;
- bumetanide;
- i-ethacrynic acid;
- piretanide.