I-Prednisolone ngendlela yamacwecwe iyisisifo esiqhelekileyo se-hormonal, esichazwe njengenxalenye yonyango oluyinkimbinkimbi kwizifo ezahlukahlukeneyo. Isilwanyana sinomphumo onamandla kwaye sisinani esikhulu sokuchasene, ngoko kuyalelwe ukuba izigulane ziqaphele kwaye emva kokuhlolwa kokuqala.
Ukubunjwa kunye nesenzo samachiza samaphilisi ePrednisolone
Into ebonakalayo esebenzayo kulolu lungiso i-prednisolone, i-analogue yokwenziwa kwamahomoni e-cortisone kunye ne-hydrocortisone efihliweyo yi-correx ye-adrenal (enye ipilisi iqukethe u-5 mg wezinto ezisetyenziswayo). Izixhobo ezixhasayo zi:
- ubisi ushukela;
- isitashi;
- i-calcium stearate.
Isilwanyana siphumelela ngokukhawuleza kwisigxina sesisu, singena kwigazi kwaye, ngokusebenza kwento esebenzayo, ivelisa umphumo wokukhusela okulandelayo:
- i-immunosuppressive (ngenxa yokuvimbela ukukhutshwa kwama-cytokines kwi-lymphocytes kunye ne-macrophages);
- Ulwaphulo-mthetho (ikakhulukazi kunye nokuthatha inxaxheba kwi-cytosolic receptors);
- ukuchasana (ngenxa yokuvimbela ukuveliswa kwe-nucleic acids kwiiseli zecala le-epidermis kunye ne-fibroblast ye-dermis);
- i-antiallergic (ngokunciphisa inani le-basophil kunye nokuchithwa ngokuthe ngqo kwintsebenziswano kunye nokuveliswa kwezinto eziphilayo);
- ukunciphisa ukwanda kwamathambo kunye nokukhula kweeseli zesisu;
- ukunciphisa i-capillary permmeability;
- ukwandisa izinga le-glucose yegazi;
- ukuqheleka kokuphefumula kunye ne- edema engioneurotic ;
- ukuhoxiswa kokubamba kunye nentlungu.
Impembelelo yokwelapha ifikeleleke kwiiyure eziyi-1.5 emva kokuthatha iziyobisi kwaye ihlala iiyure ezingama-18 ukuya kuma-36. Kufuneka kuthathelwe ingqalelo ukuba umphumo onobungozi emzimbeni we-prednisolone engabonakaliyo unokwenzeka xa kwenzeka ukuncipha kwinani leprotheni kwi-plasma yegazi. Isilwanyana sidityaniswe kumchamo kunye namanzi, ukubola, ikakhulu kwisibindi.
Imiqondiso yokusetyenziswa kwamacwecwe ePrednisolone
Ngokwemiyalelo yesilwanyana sePrednisolone Nycomed (uhlobo lwepilisi - ipilisi), izibonakaliso eziphambili zeli liyeza zi:
- impembelelo yokuguquka;
- i-asthma ye-bronchial;
- isimo se-asthmatic;
- Ukusabela kwe-thyrotoxic kunye neengxaki ze-thyrotoxic (ukhuseleko kunye nonyango);
- ukungabi nako ngokwaneleyo;
- i-hepatitis acute;
- i-cirrhosis yesibindi;
- ukutyhefuza ngamanzi afuthayo, njl
I-Prednisolone nayo inqunywe ukukhupha iimpawu okanye ukuthintela ukuqhubela phambili kwezilwanyana kwi-rheumatoid arthritis, i-lupus erythematosus, i-scleroderma, i-rheumatism, njl. Iipilisi zePrednisolone ngamanye amaxesha zichongiwe nge-oncology (ngexesha le-chemotherapy), elinceda ukukhusela ukuhlanza kunye nesiphithiphithi.
Ndiyithatha njani iPrednisone kwiipilisi?
Isilwanyana sithathwa ngomlomo ngethuba okanye emva kokutya ngokukhawuleza, ngamanzi. Iipilisi zamanani zePrednisolone, zikhethwe ngugqirha ngabanye. Njengomthetho, umthamo wokuqala ngowama-20 ukuya kwi-30 mg ngosuku (amaxesha a-2-3), ngoko umlinganiselo wesilwanyana uncipha.
Imiphumo emibi ye-Prednisolone kwiipilisi:
- kulala;
- uxhalaba;
- ukuvuvukala;
- kunyusa uxinzelelo lwegazi;
- i-humorrhea ;
- alkalosis;
- ukwanda komzimba;
- ukwanda kwegazi;
- ukwanda kwe-acidity yejusi yesisu, njl njl
Ukungqinelana kokuthatha amacwecwe ePrednisolone:
- ngxinzelelo lwegazi;
- ukuhluleka kwezintso;
- isilonda sesilonda;
- isifo sikashukela;
- endocarditis yebhakteria;
- Isifo sika-Itenko-Cushing;
- osteoporosis;
- isifo sofuba;
- i-syphilis;
- ngqondweni;
- ukukhulelwa kunye nokuhlaselwa.