I-Heparin yichiza e-antiticoagulant yesenzo esithe ngqo, oko kukuthi, inqanda ukuvalwa kwegazi. Esi sidakamizwa sikhiqizwa kwifom yefom yokusetyenziswa kwangaphandle kunye neyomziza ukwenzela ijoyi. Kodwa ngokuqhelekileyo isebenzisa isisombululo seHeparin, njengoko iqala ngokukhawuleza ukucotha ukubunjwa kwe-fibrin.
Imiqondiso yokusetyenziswa kweHeparin
Emva kokusungulwa kweHeparin, ukuhamba kwegazi ezintsheni kusebenze, ukujikelezwa kwegazi kwegazi kubonakala kwaye utshintsho lwee-enzyme ezithile luyehla. Kungeso sihlandlo esi sihlandlo sisetyenziselwa ukunyanga nokukhusela i-myocardial infarction. Ukunika isichengiselwano esinjalo kwixabiso eliphezulu kunye ne-pulmonary embolism.
Iimpawu zokusetyenziswa kweHeparin nazo zi:
- thongsis;
- angina pectoris;
- i-coronary artery thrombosis;
- i-arrhythmia;
- thrombophlebitis ;
- Ukuhamba kwegazi olubi kwiimpso;
- iintlobo ezithile zeentliziyo eziphosakeleyo;
- lupus nephritis;
- glomerulonephritis;
- endocarditis yebhakteria.
Kwizilwanyana ezincitshisiwe, le nkunkuma isetyenziselwa ukuthintela i-thromboembolism ye-venous kunye ne-DIC-syndrome yesigaba sokuqala.
Basebenzisa ii-injection ze-Heparin kunye neendlela zokungenelela, ukwenzela ukuba igazi likagulane alingahambi ngokukhawuleza.
Indlela yokusetyenziswa kweHeparin
Impembelelo ekhawulezayo iyenzeka emva kokufakelwa kwe-Heparin. Labo ababenomjovo we-intramuscular abayi kuba nako ukwenza emva kokude emva kwemihla elishumi elinesihlanu okanye imizuzu engamashumi amathathu, kwaye ukuba i-injection yenziwa phantsi kwesikhumba, isenzo se-Heparin siya kuqala malunga neyure.
Xa le nkunkuma imiselwe njengomlinganiselo wokuthintela, ininzi idla ngokufakelwa kwesisu esingaphantsi kwesisu kwiinqununu eziliwaka amahlanu. Phakathi kwama-injections anjalo kufuneka kube ngamaxesha ukusuka kwiiyure eziyi-8 ukuya kwezi-12. Kuvinjelwe ngokukhawuleza ukucoca i-Heparin ngaphantsi kwendawo enye.
Ukufumana unyango, izilwanyana ezahlukeneyo zezi zizazisetyenziswa, ezikhethwe ngugqirha kuxhomekeke kwimeko kunye nolu hlobo lwesifo kunye neempawu zomzimba wesigulane. Akunakulawulwa kweenjenge ze-Heparin kwisisu, okanye ukusebenzisa iziyobisi ngamanye amayeza, kunokumiselwa ngaphandle kokulumkisa ugqirha, ekubeni loo antiticoagulant idibanisa neyeza ezininzi. Kodwa apha kanyekanye ukusebenzisa i-Heparin kunye namavithamini okanye izithako ezisebenzayo eziphilayo ezinokwenzeka ngaphandle kokwesaba.
Ukujongana nesisombululo sokusetyenziswa kwezidakamizwa, ngenxa yokuba ayinakuxutyaniswa namanye amayeza kwisirinji enye. Izixhobo zokusungulwa kwe-Heparin kukuba emva kokulawulwa kwe-intramuscular, ukwakheka kwe-hematomas, kunye nokunyangwa kwexesha elide kunye neli liyeza, kunokubakho iziphumo:
- iimpendulo ezithintekayo;
- ukungcola okanye ukulungelelanisa;
- ukuphulwa kwe-calcium;
- iintlungu ezinjenge-migraine.
Ukungqinelana nokusetyenziswa kweHeparin
Ngoqapheli, i-Heparin kufuneka isetyenziswe ngexesha lokukhulelwa nangethuba lokuncelisa. Emva kokubonisana nogqirha unokwenza le nyilisi ingasetyenziselwa abo banesifo esithintekayo.
Ungafaki iHerparin kwisisu, nge-intravenously okanye nge-intramuscularly, ukuba isigulane sichazwe:
- isisu sesisu;
- isilitis ;
- umsebenzi wesibindi;
- iziphuzo ezinobungozi ematyeni;
- ukuxhathisa i-bacocial endocarditis;
- umsebenzi wokuguguqula;
- ngxinzelelo lwegazi;
- uhlangothi olubi;
- i-hypersensitive to the drug.
Kwakhona, ungasebenzisi izilwanyana kulabo abasandul 'ukuhlinzwa ngamehlo, ubuchopho, isibindi okanye iprotate.