Igazi lomntu liquka iintlobo ezininzi zeeprotheni, ekufuneka zibe kwindawo ethile ukwenza imisebenzi yazo. Omnye wabo ngu-fibrinogen, isixa saso esinqunywe kwi-test standard yegazi yokucima. Ukuba iziphumo ze-fibrinogen ziphakamileyo kunezinye eziqhelekileyo, oko kuthetha ukuthini, kubalulekile ukufumanisa.
Fibrinogen - yintoni na?
Enyanisweni, yiyiphi i-fibrinogen, ezininzi izigulane zinomdla xa zibona iziphumo ze-coagulogram - uphando lwebhubhorha lwegazi elimnyama, elivumela umntu ukuba ahlole amandla akhe okugcoba. Ngokuqhelekileyo, olu hlalutyo lunqunywe ngaphambi kokungenelela kwamanyathelo athile, ngexesha lokukhulelwa, ngokukrokrelwa kwezilwanyana ezithile (isibindi, intliziyo, inkqubo yesistim, njl.).
Iprotheni fibrinogen ikhiqizwa ngamathambo enyama, kwaye ingena egazini, ijikeleza apho kwiimeko ezingasebenzi. Enye yezinto zokugawula igazi. Ngenxa yesistim esichukumisayo sempendulo ekuphenduleni imiphumo ebuhlungu, isitya esichaphazelekayo sivaliwe ngumbumba oyeka ukuphuma kwamanzi. Isiseko sokwakheka kwe-clot (thrombus) yiprotheni engenayo i-fibrin, efunyenwe ngokuqhekeka i-fibrinogen ngokukhupha i-enzyme.
Ukongeza kokuthatha inxaxheba ekwakheni i-thrombus, i-fibrinogen ikhuthaza ukwakheka kwee vesicle kunye nokusebenzisana kwamaselula, kwaye ibonisa iinkqubo zokuvuvukala. Ukunciphisa kwinqanaba layo kubangela ukutshabalalisa kwegazi, okubangela ukuphuma kwegazi ixesha elide, kunye ne-fibrinogen ephezulu kukukhokelela ekuvelweni okungavamile kwe-thrombi ngaphandle kokulimala kwiindonga ze-vascular.
Ukunqunywa kwe-fibrinogen
Kwii-laboratories, i-fibrinogen egazini iyalinganiswa ngamacandelo ezinokwenziwa kwemvelo. Ukuze uphephe iimpazamo, le miqathango kufuneka ibonwe phambi kokusampula:
- ukudluliselwa komhla wokufunda ukuba kukho ukubonakaliswa kwezifo ze-catarrhal;
- ukukhutshwa kokutya, ukusela ikhofi, itiye, iziyobisi ezinxilisayo 12 iiyure ngaphambi kokuba inkqubo;
- ukupheliswa kolawulo lwee-pharmacological agents ezithintela igazi legazi, iintsuku ezimbalwa ngaphambi kokufundwa (njengoko kulawulwa ngugqirha);
- ukunciphisa umzimba, ukuphazamiseka ngokomzwelo ngaphambi kokuhlalutya;
- wenqabe ukutshaya ubuncinane ubuncinane iiyure;
- Ukuthatha iglasi yamanzi acocekileyo kwikota yeyure ngaphambi kokuthatha igazi.
I-Fibrinogen egazini - isiqhelo kubafazi
I-Fibrinogen egazini, umgangatho apho kuxhomekeke kumda womntu, kufuneka ugcinwe kwisixa semali engama-2 ukuya ku-4 g / l kumama omdala asempilweni, kunye namadoda. Kubantwana, la mazinga aphantsi. Ukuba, ngokweziphumo zoluhlalutyo lwe-fibrinogen, umgangatho wesigxina kubasetyhini uyagcinwa, oku kuthetha ukuba le prothini ihlanganiswa kwisixa esaneleyo, ubuchule bokuvalwa kwegazi abuphambuki.
I-Fibrinogen ekukhulelweni iqhelekile
I-Fibrinogen, isiqhelo sayo esilungile kubantu abanobuchopho, ishintshe indlela eqhelekileyo xa umfazi ephethe umntwana. Oku kungenxa yokwakhiwa komzimba womama wenkqubo entsha yokujikeleza, okuquka i-placenta. Kwiminyaka yokuqala, inqanaba le protheni linyuka kakhulu, kodwa kwi-trimester yokugqibela, i-fibrinogen kwabasetyhini abakhulelweyo bafikelela kwinqanaba layo, okuyimfuneko yokukhusela ukulahleka kwegazi ngexesha lokunikezelwa. Iimiqathango zilandelayo:
- I-trimester - 2,5-5 g / l;
- II trimester - 2.5-5.1 g / l;
- III trimester - 3.7-6.1 g / l.
I-Fibrinogen yanda - ithetha ntoni?
Xa uhlalutyo lubonisa ukuba i-fibrinogen iphezulu kuneyona eqhelekileyo, ithetha ukuba isiguli sinokunyuka kwe-thrombosis-occlusion ye-disk drive kunye nokuthintela ukunikezelwa kwegazi lombutho othile okanye inxalenye yomzimba. Lo mqathango usongela ukuphuhliswa kwesifo senhliziyo, i-myocardial infarction, i-stroke, i.e. yingozi kakhulu.
Ngamanye amaxesha i-fibrinogen inganyuswa kancinci okanye ixeshana ngezi zinto zilandelayo:
- ukuya esikhathini;
- ukungenelela kwangaphambili;
- ukutshisa kutshanje, enye ingozi;
- lokushisa okuphantsi.
Ukongezelela, i-fibrinogen iphezulu kuneyona eqhelekileyo kubasetyhini abathwala izidakamizwa ezine-estrogen. Kuninzi kunzulu kuneemeko apho i-fibrinogen yangexesha elide liphezulu ngaphezu kweqhelekileyo, kwaye oku kuthetha ukuba ukuvuvukala okanye ezinye iinkqubo ze-pathological occur in the body. Oku kubangelwa ukuba:
- Izifo ezivuthayo kunye nezifo ezithintekayo zendawo ezahlukileyo (isifo sofuba, pyelonephritis, pancreatitis, njl);
- neoplasms ezimbi;
- iintlobo ezinzima ze- hypothyroidism ;
- Ukufa okukhulu kwezicubu (pancreatic necrosis, i- abscess lung , i-gangrene, njl);
- izifo ezizimeleyo kwisigaba esisebenzayo (i-rheumatoid arthritis);
- umonakalo kwiinqanawa zengxubevange (i-angiopathy yesifo sikashukela, ukungakwazi ukuphefumula okungapheliyo, imivuno ye-varicose, njl.);
- i-thrombohemorrhagic syndrome (isigaba sokuqala);
- i-amyloid dystrophy, njl
I-Fibrinogen iphakanyisiwe xa ukhulelwa
Ukuba i-fibrinogen ngexesha lokukhulelwa lidlula ngaphaya komda ophezulu, izizathu zingafana. Lo mqathango usongela impilo kunye nobomi bomama ozayo, kodwa uphazamisa inkqubo yokukhulelwa. Imiphumo ingaba ngolu hlobo:
- ukukhulelwa kwangaphambili;
- ukuphazamiseka kwamaplanga;
- i-thrombosis yentambo yomlomo;
- ukuzalwa ngaphambi kokuzalwa, njl. i-fibrinogen ngaphezu kwesiqhelo ukuba oku kuthetha i-fibrinogen ngaphezu kwesiqhelo aaa ithetha ntoni
I-Fibrinogen yanda - yintoni yokwenza?
Kwiimeko apho ukwanda kwe-fibrinogen kufunyanwa, kuyafuneka ukuba kwenziwe iimviwo ezongezelelweyo ukucacisa into ebangela ukuba kubekho. Kuphela emva kokuba oku kungagqitywa yikimu lokunyanga, ejolise ekulungiseni isifo esisiseko. Ukunciphisa uxinzelelo kwimeko yeprotheni, amayeza avela kwiqela lama- antiplatelet agents , i-fibrinolytics, i-anticoagulants inokumiselwa, ukutya kunye nokunciphisa ukutya kwe-cholesterol, ukuzivocavoca kwansuku zonke, kuphakanyiswa ulawulo olwaneleyo lolawulo lokusela.