Iziyobisi ze-Antiepileptic ngamachiza anokukwazi ukukhusela ukuphuhliswa kokuthintela okanye ukunciphisa ubunzima bawo kwizigulane ezinokuxilongwa ngokuthwala. Benza ngokunyanzelisa ingqondo ngokugqithiseleyo kunye nokukhawuleza kweengonyama ebusweni, apho uhlaselo luqala khona.
Ziyasebenza njani izidakamizwa zokulwa ne-antiepileptic?
Umgaqo oqhelekileyo wezilwanyana ezisetyenziselwa ukuhluthwa kukunciphisa ngokukhawuleza kwixesha elibangelwa yi-neuronal. Kodwa zonke iindlela zeli qela zibonisa ukuchithwa okukhethiweyo komsebenzi we-neurons. Le propati yezobisi zijongene nokuhlelwa kwezidakamizwa ze-antiepileptic. Ba no ku
- ukuqinisa umsebenzi wee-neurons ezivimbelayo;
- ukuvimbela i-excitatory receptors ye-neurons;
- cha phazela ngqo ukuziphatha kombane.
Uninzi lweziphumo ezichaphazelekayo ezivela emva kokuthatha izidakamizwa zesifo se-antiepileptic azibalulekanga. Ingakwazi ukukhathala, ukufumana ubunzima okanye utywala. Kodwa kwezinye iimeko, unyango lwezonyango lukhokelela ekuphuhliseni i- psychosis okanye ukudandatheka. Kungenxa yoko, xa umntu eqala ukufumana unyango olutsha lokuhluthwa, i-dosage ilawulwa ukwenzela ukuba inqanaba elikhuselekileyo nelifanelekileyo leziyobisi liphunyezwe egazini. Njengomgaqo, kwinqanaba lokuqala lonyango, amanani angaphantsi kwesigqirha anqunywe, anqunywe kwisiqingatha sobomi beziyobisi.
Ziziphi izidakamizwa zokulwa nezidakamizwa?
Okwangoku, izidakamizwa ezininzi ze-antiepileptic zamanje zivunyiwe ukuba zonyango lwe-stempile. Ugqirha uhlala ecetyisa amayeza, ngokusekelwe kwizinto eziliqela:
- Uhlobo lokubanjwa kunye nezifo. Ezinye izidakamizwa ze-antiepileptic zakwadala okanye isizukulwana esitsha zisebenza ngokuphumelelayo ekulawuleni ukutshatyalaliswa okungapheliyo (umzekelo, i-Ethosuximide), ngelixa ezinye zichazwe kulabo abaphindaphindiweyo
(Rufinamide okanye iDiazepam). - Imbali kunye nembali yonyango yesigulane. Izigulane ezine-epilisi okanye abantwana abaneminyaka esikolweni ziqhelekileyo zibizwa nge-carbamazepine, i-phenytoin okanye i-valproate, kwaye abo baye bahlala balwa nesi sifo bahlala bebeka izidakamizwa ezintsha ze-antiepileptic (Trileptal okanye i-Topamax).
- Ukunokwenzeka kokukhulelwa. Kukho iqela lezonyango ezicwangciswe ngokukodwa kubasetyhini abanokukhulelwa. Zikhuseleke ngakumbi kumntwana okhulayo (Carba-mazepine, uLamotrigine noValproate).