Isiza seAkatinol Memantine liyeza kwiifomethe, ezisetyenziselwa ukutshatyalaliswa kwengqondo - ukwehla kwamakhono engqondo kunye nokukhubazeka kwememori, ukucinga, ukugxininisa, ukulahleka kwezakhono ezifunyenweyo kunye nezinye izinto ezingaqhelekanga.
Kwiimeko ezininzi, le ntsholongwane ikhula kancane kwaye iyabonakala kubantu abadala, kodwa ngamanye amaxesha kubonakala kubantu abaselula kunye nabantwana phantsi kwezinto ezenza ukufa kweeseli kwi-cortex ye-cerebral. Oku kunokwenzeka ngenxa yengozi ye-craniocerebral, ukuxhatshazwa, izifo, iintsholongwane zamathambo, njl.
I-Acatinol Memantine yilisi elenziwe ngumenzi onelungelo lobunikazi eliveliswa eJamani ngenkampani enkulu yezobisi iMerz, oyiphakamisi yale nkunkuma yokunyanga kwengqondo. Nangona kunjalo, namhlanje kukho amaninzi amaninzi (i-generics) ye-Akatin Memantine, eyenziwa ngabanye abenzi, kuquka nabasekhaya. Nalu uluhlu lwala mayeza, kodwa okokuqala siza kujonga ukuba ezi ziyobisi zisebenza njani emzimbeni.
I-Pharmacological action ye-Acathinol Memantine
Icandelo eliphambili lenkampani yeAkatinol Memantine, kunye neempawu zalo, i-memantine hydrochloride. Le nkunkuma, ebanjwe kumjikelezo wesisu kunye nokungena egazini, ineziphumo ezilandelayo:
- ukukhuthazwa kwe-glutamatergic system
- umgaqo wezothutho lweeon ukuya kwi-neurons;
- Ukuphuculwa kwe-nerve impulse transmission kunye nesisiseko sesizukulwana;
- ukuqhelaniswa kwamandla embrane;
- kuncipha kwi-calcium ionized kwi-neurons, njl njl.
Ngenxa yoko, oku kuphunyezwa ngolu hlobo lulandelayo:
- ukwanda kwinqanaba lomsebenzi wengqondo;
- ukwanda kwamakhono engqondo;
- ukuphucula imemori, ukukwazi ukugxila;
- ukunciphisa ukukhathala kunye neempawu zokudakumba;
- ukunciphisa iingxaki zokuthetha;
- ukwenziwa komzimba;
- ukunciphisa ukunyanzeliswa kwezihlunu zamathambo.
Ukuthatha unyango ngokusekelwe kwisigxina kukuvumela ukuba uyeke ukunyuka kwengxaki yengqondo, ukugcina izigulane zamagunya okuzinceda.
Uluhlu lweempawu ezifanayo ze-Acatinol Memantine:
- Alzheim (Argentina);
- IMemantine-TL (iRashiya);
- IMeminine (iRashiya);
- IMeicicar (eRashiya);
- ISikhumbuzo (iRashiya);
- Noogeron (Croatia);
- UAbhixa (Denmark).
Ukusetyenziswa kwe-Acatinol Memantine kunye neempawu zayo
Iipilisi ze-Akatinol Memantine, kunye nokusetyenziswa kweziyobisi, kucetyiswa ukuba zisetyenziswe ngexesha lokutya, zihlanjwe ngamanzi (akukho mfuneko yokuhlafuna). Umyinge weziyobisi ngumntu ngamnye kwisigulane ngasinye. Umthamo wokuqala, ngokomthetho, u-5 mg ngosuku. Emva kwithuba elithile, i-dosage iphakama (ininzi idla ngo-30 mg ngosuku).
Kufuneka ukhunjulwe ukuba iziyobisi ezisekelwe kwisigxina zingagqitywa kuphela ngugqirha kwaye kufuneka zithathwe phantsi kweliso lonyango. Ukongezelela, ukuba unyango lweengqondo, iimpawu eziqhelekileyo zempembelelo kumzimba kufuneka zisetyenziswe, kuquka ukutya okunempilo, ukulayisha ngokomzimba nangokwengqondo, njl njl.
Ukungqinelana nokusetyenziswa kweempawu ze-Acatinol Memantine
I-Acatinol Memantine kunye neempawu zayo zicetyiswa ukuba zisetyenziswe ngokuqaphela unyango phambi kwezi zifo ezilandelayo:
- ukuhluleka kwentliziyo;
- thyrotoxicosis ;
- ukuhluthwa;
- i-myocardial infarction;
- zixhala.
Kule meko, isilwanyana sinokumiselwa ukuba sisebenzise kumaxabiso amancinci.
Kwakhona, izilungiso ezisekelwe kummiselo alunqunyelwe ukuba:
- ukukhulelwa kunye nokuhlaselwa;
- wabonisa ukuphulwa komsebenzi weentso;
- ukunyamezela komntu kumacandelo esilwayo.