Iprolactin yenye yeeymoni ezibaluleke kakhulu kumzimba wesetyhini. Ukususela eqinisweni, kwimeko enjani ekujoliswe kuyo, ingaba umxholo wayo uhambelana neendlela eziqhelekileyo, ezininzi iinkqubo zemizimba zixhomekeka. Makhe siqwalasele ngokubanzi, yintoni ejongene neprolactin, isiqhelo kubafazi ngokudala (itafile), eboniswa yimpazamo evela kwimiqathango.
Yintoni iprolactin ejongene nayo?
Le hormone, yintsapho yeeprotheni ezinjenge-prolactin, iveliswa ngongqondo - kwindawo yangaphandle ye-pituitary gland. Ukongezelela, inxalenye yayo yokubandakanya ibandakanye ezinye izitho: izilonda ze-mammary, i-placenta, inkqubo ye-nervous, isimiso somzimba. Egazini, i-prolactin ijikeleza ngeendlela ezahlukeneyo, ihluke kwisisindo samathambo. Ipesenti enkulu ngenxa yemali yeprolactin enesisindo esisezantsi se-molecular, esisebenza ngamandla.
Imisebenzi ye-biological yeprolactin ibalwa ngamakhulu eendlela ezahlukeneyo nezenzo. Makhe sibhale imisebenzi yayo ephambili kumzimba wesetyhini:
- ukwakhiwa kweempawu zesini zesibini kwi-age-puberty;
- ukulawulwa kwemveliso yobisi ngeengcambu zentlungu emva kokunikezelwa;
- ukukhusela ukukhulelwa ngexesha lokuhlamba;
- Ukunciphisa ubuhlungu bentlungu;
- ukuxhasa ukusebenza komzimba ophuzi ovelisa i-progesterone;
- ukukhuthaza ukuvuthwa kwe-follicle kunye ne-ovulation;
- ukulawulwa kwamanzi-electrolyte balance;
- ngokuqhelekileyo iinkqubo zokuxilisa;
- ukucebisa amathambo amathambo kunye ne-calcium;
- ukukhuthaza ukukhula kwemithambo yegazi entsha;
- ukwakheka kwintsimi yesisu;
- ukuphuhliswa kwesondo, njl njl
Uhlalutyo lweprolactin
Kwixesha leemvavanyo zegazi eliqhelekileyo le hormone ayinqunywanga, baninzi abantu banombuzo xa bathabatha iPlactin. Ngokuqhelekileyo, ulwalathiso olwenziwe kwisifundo esinjalo lunikezwa ngumgqirha-gynecologist-endocrinologist phambi kwezikhalazo, ezinokuthi zidibaniswe nokuphulwa kobungozi bezinto eziphilayo ezicwangcisiweyo. Ngoko, ngokuphindaphindiweyo igazi linikezelwa ngeprolactin xa kunomjikelezo, ukukhutshwa okungavumelekanga kwimbilini, ukungabikho kwexesha lokukhulelwa, ukukhula kweenwele ebusweni, iingxaki zesikhumba, njl njl.
Ukufumana umphumo onokuthenjelwa, akufanele ucinge nje ngoluphi usuku lomjikelezo ukunika iprolactin, kodwa ugcine ezinye iimigaqo kwaye wenze amalungiselelo okulungiselela. Imithetho ephambili yokuhlalutya le hormone ilandelayo:
- Isampululelo segazi senziwa ngomhla we-3-5 womjikelezo wesini;
- Isampuli ithathwa kwi-vein vein in esiswini esingenalutho ekuseni, iiyure ezingama-3 emva kokuvuswa;
- Ngaphambi kokuba isifundo singakhange sihambele i-sauna, ulwandle, ukuthatha ibhebha elitshisayo, i-hypothermia, ukuthandana ngokwesondo, ukwenza umsebenzi;
- Ngomhla wokutya, kuyadingeka, ngaphandle kokutya okuninzi, ukunciphisa iimveliso zeeprotheyini nokuphelisa utywala;
- ngaphambi kokuba kuthathe igazi kufuneka kuphelelwe ukuthukuthela ngokomzwelo;
- Ngentsasa phambi kokuvavanywa, awukwazi ukutshaya nokuchaphazela indawo yeengono.
Ngenxa yobukhulu bobukhulu beli hormone kwiimpembelelo ezininzi zangaphandle nangaphakathi, ukwenzela ukuphepha izikhombisi ezingalunganga, iingcali ezininzi zincoma ukunikela ngegazi ukuze zifundwe kathathu ngezikhathi zenyanga. Iziphumo ziyaziwa ngosuku olulodwa, kwaye ugqirha kufuneka ahumushe izibonakaliso aze enze ukuxilongwa.
Iprolactin - isiqhelo kubafazi (itafile)
Uxinzelelo oluqhelekileyo lweprolactin egazini lihluka ngoxhomekeke kwiminyaka, inani le-estrogen eveliswayo, ukukhulelwa, ixesha lokuncelisa, njl njl. Ukwenza kube lula ngakumbi ukutolika umphumo we-hormone prolactin kwisiqulatho kwabasetyhini, itheyibhile eneemeko ngokudala ibuyisela ngokucacileyo ixabiso lokuziqhelanisa.
Ixesha elide | Isiphumo esiqhelekileyo, md / l |
olutsha | 1700-2000 |
ukuya ku-1 unyaka | 630 |
1-10 iminyaka | 40-400 |
11-16 ubudala | 40-600 |
Iminyaka eyi-16-45 (iminyaka yobudala) | 40-600 |
45 nangaphezulu (ukuyeka umyeni) | 25-400 |
Njengoko kunokubonwa etafileni, ngokwemilinganiselo ye-hormone prolactin, isiqhelo kubasetyhini siyafana nangeminyaka emva kokuphelelwa komntwana kunye nangaphambi kokunyuka kwexesha. Kufuneka ukhunjulwe ukuba ukuguqulwa kwemihla ngemihla kuvunyelwe, kuxhomekeke kubuthongo, ukutya, ukuxinezeleka, izenzo zesondo, imiphumo yokushisa, njl njl. Ukongezelela, ukuhlanganiswa kwesi sakhiwo akufani kwimihlathi eyahlukeneyo yomjikelezo wesini. Oku kuqwalasela imithetho yokulungiselela ukuhlalutya.
Iprolactin ekukhulelwe iqhelekileyo
Iprolactin, isantya apho abafazi xa bethatha utshintsho lwabantwana ngenxa yeenkqubo ezininzi zomzimba emzimbeni, baqala ukunyuka ngokuthe ngcembe kwi-trimester yokuqala kwaye bahlala bephakanyisiwe kude kube kuthunyelwa (kuphela iintsuku ezimbalwa ngaphambi kokuzalwa, kuncipha kancane). Kule meko, itekisi elandelayo iyasebenza, apho umgangatho wenkqubo yeprolactin yabasetyhini ibonakaliswa yiminyaka yobudala, kodwa ngexesha lokukhulelwa.
Ixesha lokuzala umntwana | Isiphumo esiqhelekileyo, md / l |
8-12 iiveki | 500-2000 |
Kwiiveki ezi-13-27 | 2000-6000 |
ukususela kwiiveki ezingama-28 | 4000-10000 |
Uhlalutyo lweprolactin ekukhulelweni alufanekanga, kwaye iingcali ezininzi zijonga ukuba zingenaso ulwazi, ngenxa yokungafani okukhulu phakathi kweziphumo eziqhelekileyo. Ukuba loo mfuneko ivela, ngoko-ke njengesiqhelo bakhokelwa yixabiso le-10000 mU / l, elingafanele lidlulelwe, ukuba yonke into emzimbeni womfazi kunye nekamva elizayo liqhuba kakuhle.
Iprolactinum kwi-lactemia - umgangatho okanye izinga
Emva kokunikezelwa, umgangatho weprolactin uxhomekeke kuhlobo lokuncelisa. Kwimeko apho kukho ukutya okufakwayo ngaphandle kokufaka isicelo kwisifuba, kancane kancane inani le hormone lisetyenziswe kwinqanaba le-400-600 mU / l. Ukuba ibhinqa ibele, ngokuphindaphindiweyo umntwana usana, uphakamileyo kwinqanaba. Le tafile elandelayo iya kukuxelela inani eliqhelekileyo le-hormone prolactin (ngokuqhelekileyo, kuxhomekeke kwithuba lokutya).
Ixesha lokubambisana | Isiphumo esiqhelekileyo, md / l |
kwiinyanga 6 zokuqala | 2500 |
Iinyanga ezi-7-12 | 1000-1200 |
kwiinyanga ezili-12 | 600-1000 |
Iprolactin ekumiseni kwindoda iyaqhelekileyo kubafazi
Emva kokuphela kokuphela kokuya esikhathini, xa i-hormone enkulu yokuhlelwa kabusha kwe-hormonal ivela emzimbeni wesifazane, izinga leprolactin, njengamanye ama hormone, liqala ukuhla. Ngokomyinge, ixabiso lalo nyaka ububanzi lisuka kwi-25 ukuya ku-400 mU / L (idatha iqulethe i-table - prolactin, isiqhelo kubasetyhini ngama-age). Unyaka ngamnye ezi xabiso ziyancipha.
I-Hyperprolactinemia kwabasetyhini - yintoni na?
Ukuba uhlalutyo lubonisa ukuba i-prolactin iphakanyisiwe kumfazi, ngelixa engakhulelwe, ayinasondli, zonke iimeko zokuqokelela igazi zidibeneyo (oko kukuthi, izinto zokuphila zonyusa ukuhlanganiswa kwayo akugcinwa), umntu kufuneka akhangele isizathu esibhedlele. Le meko ibizwa ngokuba yi-hyperprolactinemia kwaye kwiimeko ezininzi kufuneka zilungiswe.
Izizathu zokunyuka kweprolactin
Iprolactin ephezulu ingabangelwa ngamaqela amathathu ezibangela:
1. I-Organic:
- izicubu ze-pituitary gland (prolactinoma, adenoma, meningioma, njl);
- izicubu ze hypothalamus (glioma, germinoma, njl);
- iicysts zeengqondo;
- iziphene ze-hypothalamus;
- irradiation yommandla we-hypothalamic;
- isifo sokunqunyulwa komlenze webhunga le-pituitary, njl.
2. Ukusebenza:
- i-cirrhosis yesibindi;
- i-hypothyroidism ephambili;
- ovary polycystic;
- lupus erythematosus;
- ukungaphumeleli kwindlala;
- ukungakwazi ukusebenza kwe-correnx ye-adrenal;
- iindlela zokugonywa kwi-thorax;
- ngqungquthela, njl
3. Amayeza okusebenzisa iziyobisi:
- antiemetics;
- antipsychotics;
- i-estrogen equkethe amalungiselelo;
- antihistamines;
- abaxhamli be-calcium , njl
I-Hyperprolactinaemia kwabasetyhini - iimpawu
Ukwanda kweprolactin kudla ngokuhamba kunye nezi zilandelayo zibonakaliso zekliniki:
- ukukhutshwa kwiintlobo zeentloko;
- intlungu kwiintlanzi ezincinci;
- izibilini kwisifuba;
- ukuma komfazi ;
- izibandezelo zomjikelezo wesini;
- ekhanda rhoqo;
- ukunyameka kwengqondo;
- ukuwohloka kombono;
- u bunzima;
- kunciphisa libido;
- seborrhea ye-scalp ;
- intsimbi;
- Ukukhula ngokunyuka kweenwele emzimbeni;
- ukuphazamiseka kokulala, njl
I-Hyperprolactinemia kwabasetyhini - unyango
Ukuba, ngokwemiqathango yokuhlolwa kwegazi, i-hyperprolactinaemia isungulwe kwabasetyhini, kukho ukubonakaliswa okungenabungozi, iinkqubo ezongezelelweyo zokuxilongwa zicetyiswa ukuba zenze izifo ezibangelwa ngumzimba, phakathi kwazo:
- iimvavanyo ze-hormone ze-thyroid, ii-hormone zesondo;
- vavanyo lwegazi;
- I-ultrasound ye-thyroid gland , izitho zeplavic, isisu somzimba;
- i-resonance yamagnetic okanye i-tomography ecatshulwa yengqondo.
Unyango luxhomekeke kwizinto ezingekhoyo. Kwimeko yokufumanisa i-neoplasms yengqondo, unyango ogqityiweyo, oluqhelekileyo ludibene ne-radiotherapy, lunokumiselwa. Kwezinye iimeko, iindlela eziphambili zonyango ziyonyango, ijoliswe ekupheliseni imbangela engundoqo. Ukongeza, ngokuthe ngqo ukunciphisa ukuxinwa kwale hormone, iziyobisi ze-dopaminomimetic (i-Bromocriptine, i-Kabergolin, njl. Njl) ingachongwa.
Prolactin e nciphisa
Iprolactin ephantsi ayiqhelekanga, kwaye izizathu eziqhelekileyo zilandelayo:
- ukukhulelwa kwangaphambili;
- i-postpartum infarction ye-pituitary gland;
- ukuthatha imithi ethile (i-anticonvulsants, iziyobisi ze-dopaminergic, njl.).