Uninzi lwagqirha lithetha ngokuqinisekileyo ukuba i-Methotrexate kwi-rheumatoid arthritis iyona ndlela iphumelele ngayo izidakamizwa ezisisiseko ezichasayo. Iyanciphisa kakuhle ukukhushulwa kwaye igcina ukuxolelwa okuzinzile kwesi sifo.
Unyango lwe-methotrexate i-rheumatoid arthritis
Isilwanyana savela ngokukhawuleza, malunga neshumi nesigamu esidlulileyo. Yibhale kwinkqubo enzima yokwenza i-rheumatoid arthritis. Inqanda ukuhanjiswa kunye nokulungiswa kwe-DNA, kunye ne-mitosis yamaselula, evumela ukuyeka ukusabalala kwezicubu. Yingxowankulu ye-antimetabolites, ezichasayo. Ngaba i-immunosuppressive good.
Ukusetyenziswa kwe-methotrexate kwi-arthritis ye-rheumatoid kuye kwaba nethuba kwiiveki zokuqala. Ukongezelela, idluliselwa ngokulula ngaphezu kwezinye iindlela zokonyango. Ngokuqhelekileyo oogqirha ngaphambi kokuba uhlalutyo lokugqibela lubekwe lo muthi ukuze ungaphutheli ixesha kwaye uphumelele ukubuyisela kakuhle kwisilumkiso sokugula.
Isicwangciso sokwamkelwa kunye neentlobo zemveliso yokwelapha
I-Methotrexate ifumaneka kwiindlela ezininzi:
- amaphilisi aphekiweyo (2.5, 5, 10 mg);
- isisombululo somjovo (10 mg);
- gxininisa ukulungiselela isicombululo.
Isistim of methotrexate kwi-rheumatoid arthritis ekuqaleni kwonyango i-7.5-15 mg ngeveki. Kule meko, le nkunkuma ilawulwa kakuhle kwizidanga ezintathu ezihlukeneyo, nganye iiyure eziyi-12. Kwiinyanga ezintathu, i-dose yanda ukuya kuma-20 mg ngeveki. Kufuneka kuqatshelwe ukuba kubaluleke kakhulu ukubala ngokuchanekileyo inani leziyobisi kwisigulane, njengoko oku kungakhokelela kwimiphumo emibi yempilo, umzekelo, isibetho se-pneumonia. Njengoko umyalelo we-Methotrexate uthi, nge-rheumatoid arthritis i-dose ephezulu ayifanele idlule i-25-30 mg ngeveki.
Ekugqibeleni i-dose ephakanyisiweyo ye-methotrexate kwi-arthritis ye-rheumatoid ithathwe ngokunyanisekileyo. Oku kubangelwa ukuba ukukhanselwa ngokukhawuleza kweziyobisi kunokukhokelela ekugqibeleni kwesi sifo. Ukunciphisa umlinganiselo kufuneka ube malunga nama-2.5 mg.
Kwalabo abangenakusebenzisa iyeza ngendlela yamacwecwe ngenxa yokubonakala kwengcamango yokuhlanza, ii-injections zivame ukunyulwa. Kufuneka kuqatshelwe ukuba ii-injection ze-methotrexate kwi-rheumatoid arthritis zisebenza kakuhle kwaye zikhethwayo. Oku kungenxa yokuba iipilisi ziyakuchaphazela umsebenzi wegciwane lesisu, kwaye umphumo wabo uqala emva kwexesha. Isixa sesisombululo esifanelekileyo sibalwa ngokusekelwe kummandla womzimba kunye nobukhulu bayo. Uninzi lwamaxesha amaninzi, iilenki zinikezelwa kanye, kwaye ukusuka kumqulu u-7.5 ukuya ku-15 mg.
Impembelelo yeziyobisi ibonakala ngokukhawuleza ngeveki yesihlanu yokungeniswa, kwaye ubuninzi bayo bunokufikelela emva konyaka. Njengoko iimali ezongezelelweyo zichazwe i-analgesics ekhethekileyo, kunye ne-non-steroidal anti-inflammatory drugs, i-ointments kunye ne-physiotherapy.
Imiphumo emibi
Ukusetyenziswa kwe-methotrexate kwi-rheumatoid arthritis inoluhlu lweempembelelo ekufuneka ulungiselelwe:
- isicefe
- isifo sohudo;
- ukuhlanza;
- intloko;
- stomatitis ;
- izilonda kwi-mucosa yomlomo;
- ukungabikho koqhagamshelwano;
- ukwanda kwama-enzymes;
- ukwakheka kwe-thrombi;
- ukuphazamiseka kwenkqubo yokuphefumula.
Ukungqinelana kokuthatha isilwanyana
I-Methotrexate ayivumelekanga kubasetyhini abakhulelweyo okanye ngexesha lokutya. Musa ukuthatha eli liyeza kunye nabantu abanezifo ezinzulu zesibindi, iintso kunye ne-hemopoiesis.
I-Methotrexate kufuneka igwenywe kunye ne-antibiotics yamaqela:
- tetracycline ;
- sulfonamide;
- salicylates;
- bharbiturates;
- cyclophosphamide;
- doxorubicin.
Kwakhona, kufuneka uyeke ukuthabatha izityalo ze-biological, ezibandakanya isinyithi, i-folic acid. Zonke ezi ziyobisi zingasebenzisana kwaye zikhokelela ekutyhileni umzimba.