Izifo ezibangelwa zizifo kunye neebhaktheriya ziba zizibangela zezifo ezinzima zesimo sokuphefumula, inkqubo ye-urrogenital kunye namanye amalungu omzimba. I-Fluoroquinolones yezizukulwana zakutshanje ngokuphumelelayo. Ezi ziyobisi ezinokubulala i-antimicrobial ziyakwazi ukunqoba kunye nezifo ezinganyangekiyo kwi-quinolones kunye ne-fluoroquinolones, ezisetyenziswe iminyaka emininzi edlulileyo.
Iifluoroquinolones izizukulwana ezi-4 - ziphi na iziyobisi?
I-Fluoroquinolones sele isetyenziselwe ukulawula i-microbes ukususela nge-1960, ngeliphi ixesha iibhaktheriya ezibonakala zikhuselekile kwiininzi zamachiza. Yingakho izazinzulu aziyeki apho kwaye zivelise izidakamizwa ezintsha kunye nezitsha, zandisa ukuphumelela kwazo. Nazi amagama ezizukulwana zokugqibela ezivela kwi-fluoroquinolones kunye nabaphambili babo:
- Ukulungiselela isizukulwana sokuqala (i-nalidixic acid, i-oxolinic acid).
- Izidakamizwa zezizukulwana zesibini (lomefloxacin, norfloxacin, i -loxacin, i-pefloxacin, iprofloxacin).
- Ukulungiselela isizukulwana sesithathu (levofloxacin, parfloxacin).
- Ukulungiselela isizukulwana sesine (moxifloxacin, hemifloxacin, gatifloxacin, sixfloxacin, trovafloxacin).
Isenzo sesizukulwana esitsha se-fluoroquinolones sisekelwe ekufakeni kwabo kwi-DNA ye-bacteria, apho i-microorganisms ilahlekelwa khona amandla okuphindaphinda nokufa ngokukhawuleza. Ngesizukulwana ngasinye, inani le-bacilli ekubhekiselele kuyo iziyobisi. Kuze kube yiminyaka, oku kuku:
- E. coli;
- Pseudomonas aeruginosa ;
- intonga ye-gnofilnaya;
- shigella;
- salmonella;
- ikholera intonga;
- hominococci;
- i-meningococci;
- Campylobacter;
- chlamydia;
- mycoplasma;
- pneumococci;
- staphylococci .
Akumangalisi ukuba ezininzi i-fluoroquinolones ziluhlu lweempawu ezibalulekileyo kwaye ziyimfuneko - ngaphandle kwazo akunakwenzeka ukunyanga i-pneumonia, ikholera, isifo sofuba nezinye izifo eziyingozi. Iimpawu ezincinci kuphela apho olu hlobo lonyango alukwazi ukuchaphazela zonke ii-bacterial anaerobic.
Yintoni i-fluoroquinolones kwiipilisi?
Okwangoku, iipilisi zikhutshwa ngokuphefumula kwe-fluoroquinolones ukulwa nezifo zokuphefumula eziphezulu kunye nezantsi, iziyobisi zonyango lwezonyango ze-genito-urinary kunye
- Levofloxacin;
- Moxifloxacin;
- Sparfloxacin;
- INorfloxacin nabanye.
Ngaphambi kokuba uqale unyango, ufunde ngokunyanisekileyo ukuchasene - ezininzi iziyobisi zeli qela azange zinconywe ukuba zisebenzise ngokuphulwa komsebenzi osisigxina, izifo zesibindi kunye nesibindi. Kubantwana kunye nabasetyhini abakhulelweyo, i-fluoroquinolones iboniswe ngokuchanekileyo ngokwemigqaliselo yesigqirha xa kuziwa ekulondolozeni ubomi.