Nangona kukho inkqubela enkulu yeyeza kunye nempumelelo ekuchazeni i-genetic code, i- rheumatoid arthritis isesinye sezifo ezinzima kakhulu eziyingozi. Le ntsholongwane inemvelaphi engezantsi, izizathu eziphambili zokuphuhliswa kwayo azikabikwa. Ngokumalunga nalokhu, izazinzulu zenze iziko lophando, zihlala ziphuhliswa rhoqo unyango olusebenzayo lwe-rheumatoid arthritis - iziyobisi zesizukulwana esitsha esisebenza ngokukhawuleza kunabo abandulelayo. Ukongeza, ii-agent ezinjalo zenza ukuba izigulane ezingekho phantsi kweziphumo zingalunganga kwizigulane, zibekezele ngakumbi.
Ukulungiselela unyango lwe-rheumatoid arthritis
Unyango lwesi sifo esibhekiselweyo lubandakanya amaqela amabini eziyobisi:
- ezichasayo ;
- siseko.
Uhlobo lokuqala lwamayeza lusetyenziswe ukuphucula ngokukhawuleza kwentlungu ehlangene kunye nezinye iimpawu zesifo se-rheumatoid arthritis, unyango lwayo lwezonyango.
Izilungiselelo ezisisiseko ziphucisa ukunyuka kwe-pathology okanye idlulise inkambo yayo ibe yindawo yokuxolelwa, ngokulawula ngokuthe ngqo iindlela zokuphuhliswa kwesifo, ukunqanda umsebenzi we-immune system.
Esikhundleni samachiza angagqitywanga, angabangeli nje kuphela iziphumo ezininzi, kodwa asebenze ngokukhawuleza (ngaphezu kwexesha leenyanga eziliqela), i-biological agents ifikile. Ukulungiswa kobunjineli be-genetic kwi-rheumatoid arthritis kuthintela umsebenzi wokuzikhusela, oko kukuthi - ukucima umveliso weeseli ze-cytokine ezivusa iinkqubo zokuvuvukala kunye nomonakalo ohlangeneyo. Inzuzo enkulu ye-biological agents ikwazi ukusebenza kuphela kwiqela elinye lamaqela omzimba, ngaphandle kokuchaphazela ezinye iindlela. Ngaphezu koko, loo myeza ikuvumela ukuba ufumane iziphumo ngokukhawuleza kunokuba usebenzisa izidakamizwa ezazisetyenziswa ngaphambili, umphumo ochaziweyo uvele uvele kwiiveki ezi-2-4 ukusuka ekuqaleni kokungeniswa.
Amachiza obunjineli be-genetic kwi-rheumatoid arthritis nayo iquka iziyobisi kunye nama-antibodies ezi-monoclonal kwi-receptors ye-B-lymphocyte-iiseli ezibandakanyekayo kwinkqubo yokutshatyalaliswa kunye kunye nokukhubekisa. Enyanisweni, iziyobisi ezichazweyo nazo ziyakunqanda ukuveliswa kwee-cytokines, kodwa kusekuqaleni kwamanyathelo okubunjwa kwazo, "kwi-bud."
Uluhlu lwezilwanyana eziza kutsalwa kwonyango lwe-rheumatoid arthritis
Amacandelo e-biological agqitywa kwicandelo langaphambili angagqithiselwa ngokwemimiselo eyahlukeneyo ngokwemigangatho yesenzo sabo. Namhlanje, iziyobisi ezitsha zilandelayo zisetyenziselwa ukuphatha i-rheumatoid arthritis:
1. I-Interleukin-1 inhibitors:
- I Kinneret (anakinra).
2. Abavimba be-tumor necrosis okanye i-TNF-blockers:
- Remicade (infliximab);
- Enbrel (etanercept);
- Humirae (adalimumab).
3. Iindlela eziphazamisana nomsebenzi we-B-lymphocytes:
- Rituxan (rituximab).
4. Amayeza anqanda ukusetyenziswa kwamaseli e-immune T:
- Orence (abatacept).
Ngeli xesha, onke amayeza adwelisiweyo akhiqizwa phesheya kwaye akanayo amafanane.
Ngaba izidakamizwa ezitsha zizalisekile kwi-arthritis ye-rheumatoid?
Ngokutsho kophando lwezobugqirha kunye nokuphononongwa kweengcali ze-rheumatologists, kwakunye nezigulane zabo, iziyobisi eziboniswe ngokukhawuleza kwaye zenze igalelo elihle nakwiimeko ezinobungozi. Ucwaningo luye lwabonisa ukuba umntu wesithathu wabantu abahlukunyezwa yi-rheumatoid arthritis baqhubeka bexolelwa ngokugula emva kokusetyenziswa kwee-biological agents.