Isifo seCreutzfeldt-Jakob sisifo esingavamile esichaphazelekayo ngengqondo ngenxa yokubonakala kwiprotheni engaqhelekanga kwi-neurons kwaye kuthiwa izazinzulu ezazisichaza okokuqala. Inkqubo yokukhubazeka kakhulu phakathi kwabantu abaneminyaka engama-65 ukuya kuma-70.
Iimbangela ze-Creutzfeldt-Jakob syndrome
Kuye kwasungulwa ngokwesayensi ukuba isifo seCreutzfeldt-Jakob sisifo esithathelwanayo. Kuyaziwa ukuba kwiiseli zesisongela zengqondo kunye nezinye iiseli zomzimba womntu kukho iprotheni eqhelekileyo, imisebenzi yayo iyahlala ingacacanga namhlanje.
Iprotheni engavumelekanga yokungena kwintsholongwane, engena emzimbeni womntu, ingena kwingqondo ngegazi, apho iqokelela kwi-neurons. Ukongezelela, i-prion pathological, edibana neprotheni eqhelekileyo yeeseli zengqondo, ibangela utshintsho kwisakhiwo sayo, ngenxa yoko ekugqibeleni iguqulwa ibe yifom ye-pathogenic efana ne-prion echaphazelayo. Izibhengezo ezingavumelekanga zifake iiplates kwaye zibangele ukufa kwe-neuronal.
Usulelo lwe-pathogenic prions lungenzeka ngeendlela ezilandelayo:
- xa ukutshintshela izicubu ezinesifo (isikhumba, i-cornea yelihlo, igobolondo elukhuni yengqondo);
- ngokusebenzisa isixhobo somnxeba esingasifanelanga;
- ngegazi;
- ngokuqaliswa kweziyobisi ze-hormonal (i-gonadotropin yabantu, i-somatotropin);
- xa udla inyama yezilwanyana ezigulayo okanye abathwali bezonyango (iinkomo, ibhokhwe, njl.).
Kwakhona, enye yezinto ezibangela isifo sisigxina sezinto eziphilayo ezihambelana nokuguqulwa kwamagciwane. Ezinye izifo zesifo zivela kwimvelaphi engaziwayo.
Iimpawu zeCreutzfeldt-Jakob
Isifo seCreutzfeldt-Jakob sinexesha elide lokuxubusha, elidibaniswa nexesha lokungena kwamathambo okusuleleka kwisifo seengqondo kunye neenguqu ze-pathogenic kwizibhedlele eziqhelekileyo zenzeka. Kuze kube nini le nkqubo inokuxhomekeka kwindlela yokusuleleka. Ngoko, xa usuleleko lweengcambu zengqondo kunye nezixhobo ezingenayo igciwane, le sifo siphula emva kweenyanga ezili-15 ukuya kwezingama-20, kwaye xa amayeza asulelekile, emva kweminyaka eyi-12.
Uninzi lwesifo seCreutzfeldt-Jakob sinokuphuhliswa kokuqhubeka. Kukho izigaba ezintathu zesifo, ezibonakala ngeempawu ezahlukeneyo:
1. Isigaba seempawu ezibonakalayo:
- ukucaphuka;
- kunzima ukugxila;
- intloko ;
- ukungcola;
- izifo zokulala;
- ukunciphisa ubuqhetseba obubonakalayo;
- utshintsho kwiimpendulo zokuziphatha;
- uloyiko loloyiko olungenanto;
- amava ahlazo;
- ukungaqiniseki kwemali;
- ukuphulwa kwemisebenzi yokubala, ukufunda.
2. Isigaba semiboniso yeklinikhi ebonakalayo:
- ukukhubazeka okwenyukayo (kwinqanaba elingaphansi okanye eliphezulu, isigxina somzimba);
- ukuphazamiseka kokulungelelaniswa kweminyango yokuzithandela;
- ukuxhwaba ;
- ukuqina komzimba;
- ukuthuthumela, athetosis;
- myoclonus;
- iingxaki zokuthetha;
- ukukhathazeka kwengqondo.
3. Isigodlo sesigxina - esichazwe yimiqondo ejulile, apho izigulane zihlala kwiindawo zokungcolisa, ukungaboniswanga. Kukho i-musrotic atrophy eqinile, i-hyperkinesia, ukugwinya iingxaki, ukuxhatshazwa kwe-hyperthermia kunye nokuhlutha kwesifo.
Unyango kunye nesiphumo se-Creutzfeldt-Jakob
Esi sifo kuzo zonke iimeko kubangela ukufa. Ubomi bentsholongwane yesigulane asikho ngaphezu konyaka omnye ukususela ekuqaleni kokuqala kwesi sifo. Okwangoku, ukufikelela kwonyango oluthile luphuhliso olusebenzayo, kwaye izigulane zifumana kuphela unyango olumqondiso.