Enye yezona zibonakaliso zibalulekileyo, oogqirha abazifundayo ngeenkcukacha ngexesha loxinano lomfazi, yi- fibrinogen . Yiprotheyini edlala indima enkulu kwinkqubo yegazi. I-Fibrinogen ikhiqizwa iiseli zesibindi, ngoko, ukungena egazini, ngaphantsi kwefuthe le-thrombin liguqulwa libe yi-fibrin. Ukuhlalutya kwegazi nge-fibrinogen, okuqhelekileyo ekumiselwe kwibhubhoratri, kubaluleke kakhulu, kokubili kumama nakumntwana. Kungenxa yefrinta leyo ifomu ye-thrombi, eyanciphisa ukulahleka kwegazi ngexesha lobasebenzi.
Isiqhelo se-fibrinogen egazini
Isiqhelo se-fibrinogen kubasetyhini abasemgangathweni ngu-2-4 grams kwitha nganye. Ngexesha lophuhliso lomntwana esiswini, zonke iinkqubo zomzimba wexesha elizayo lonina zifumana utshintsho oluninzi, kwaye kwinqanaba le protein linentsingiselo eyahlukileyo. Ngoko, izinga le-fibrinogen ekukhulelwe lifikelela kuma-6 amagremu kwi-1 litre yegazi. Esi sibonakaliso siqala ukwanda ukusuka kwiinyanga ezi-3, kwaye ekupheleni kokukhulelwa kufinyelela ekuphezulu. Oku kubangelwe kukuphuhliswa kwenkqubo ye-circulatory ye-utero-placental. Ukongezelela, ngexesha lobasebenzi, kukho umngcipheko wokulahlekelwa ngumthamo omkhulu wegazi, ngoko umzimba uqala ukuvelisa iiprotheyini, egalela ekusebenzisaneni kwayo.
Ukuqaphela umgangatho we-fibrinogen, owesifazane okhulelwe unikezelwa uvavanyo lwegazi - i-coagulogram. Uhlalutyo lunikezwa kusasa ngesisu esingenalutho ngokuthatha igazi eminwe okanye kwimvini. Uhlalutyo oluthe ngqo lubizwa ngokuba yi-hemostasiogram. Ugqirha ubeka uhlalutyo kwi-1st, 2nd and 3rd trimester yokukhulelwa. Esi sibonakaliso sinokuhluka ngokuxhomekeke kwimeko jikelele kunye nobude bokukhulelwa. Ngoko, kwi-trimester yokuqala inqanaba le-fibrinogen lingaguquka ukusuka kwi-2.3 g ukuya kwi-5 g, okwesibini - ukusuka kwi-2.4 g ukuya kwi-5.1 g, kwaye kwisithathu-ukusuka kwi-3.7 g ukuya kwi-6.2 g.
I-Fibrinogen - engaqhelekanga kubafazi abakhulelweyo
Naluphi na ukuphambuka kwesohlwayo, inkqubo yokucima igazi iphazamisekile, i-fibrinogen ephantsi okanye ephakamileyo ngexesha lokukhulelwa lihlala lidala ugqirha olunzulu malunga nempilo yengane engakazalwa kunye nemiphumo ekhuselekileyo yomsebenzi. Kwimeko apho i-fibrinogen iphezulu kuneyona evamile, kunomngcipheko weengxowanzelo zegazi kwiimithana yegazi, ezinokubangela ukuphulwa komsebenzi we-cardiovascular. Ukunyuka kwesi sixalathisi kunokubonisa ukuba kukho ubuqhetseba kwinkqubo yomfazi okhulelweyo-intsholongwane, ukusuleleka, okanye inkqubo yokufa kwesisu. Le meko ingabonwa xa ibhinqa ligula ngengumkhuhlane, i-ARVI okanye i-pneumonia.
Ukuhla kwe-index kungakhokelela ekulahlekelweni okukhulu kwegazi ngexesha lomsebenzi. Isizathu sokuthi i-fibrinogen ekukhutheni iyancipha, kunokubakho i-toxicosis efikeleleka (gestosis) okanye ukungabikho kwamavithamini B12 kunye neC. Esinye isizathu sokungabikho kwemveliso yeprotheni yi-DIC syndrome. Esi sifo, esihambelana nokuphulwa kwegazi lokucima ngokuphathelele kwimveliso yezinto ezininzi ze-thromboplastic.
Kukho iimeko ezinzulu xa i-fibrinogen isezantsi kakhulu kunexesha eliqhelekileyo, okubangela ukuba umzimba wesetyhini okhulelweyo ukhulise i-hypofibrinogenemia. Esi sifo sinokubakho kokuzalwa kunye nokufumana. Kwimeko yokuqala, iprotheni ingaveliswa, kodwa ayizalisekanga imisebenzi yayo, okanye ayivelwanga nhlobo. Ifomu efumanekayo yesifo iyabonwa kuphela xa ukhulelwe. Kule meko, isibonakaliso sancitshiswa sibe yi-1-1.5 grams
Isizathu sokuphuhliswa kwe-hypofibrinogenemia kumfazi okhulelwe kungabikho ukuphazamiseka kwamaplazi, ukufa komntwana kunye nokuhlala kwakhe kwithuba esibelethweni, okanye ukubandakanya i-amniotic fluid (ivela ngenxa yokungena kwe-amniotic fluid kwigazi lomama).
Uhlalutyo olumgangatho we-fibrinogen ngenye yeendlela ezibalulekileyo zokubonwa kwangaphambi kokubeletha. Le ndlela ikuvumela ukuba ungabandakanyi okanye uqaphele ingozi ebalulekileyo yokuphuhliswa komntwana kunye nekhosi yabasebenzi. Ngoko ke, kuyimfuneko ukuba rhoqo uphando kwaye ulandele iziphakamiso zogqirha wakho.