I-Orthanol yisiza esiseqela leproton inhibitors. It has action antiulcer. Isetyenziselwa ukuvimba ukukhutshwa kwe-hydrochloric acid kunye nokunciphisa umxholo wayo kwindlela yokugaya.
I-Pharmacological action Ortanol
Into ehamba phambili yonyango nguOrtanol - omeprazole. Izixhobo ezincedisayo-talc, i-lactose, i-giprolose kunye ne-croscarmellose sodium. I-Ortanol ifumaneka ngendlela yeefomsile.
Le chiza liyanciphisa umveliso we-acid. Isebenza njenge-pro-drug, eqala ukusebenza kwiimfihlo zecala zesisu ngeeyure ezingama-2. Ngokomzekelo, i-Ortanol imiselwe ukutshabalalisa ukukhutshwa ngokukhawuleza kwe-GIT secretion. Iyeza lihlala ixesha eli-24. Iziphumo eziphambili zephemokhali zonyango zifezekisiweyo ngexesha lokunyanga, elimele lihlale ubuncinane iintsuku ezingama-5, kodwa zidlule iintsuku ezi-7 emva kokugqiba. Emzimbeni womntu, i-Ortanol idityaniswe yizintso.
Imiqondiso yokusetyenziswa kwe-Ortanol
Iyeza limiselwe kwimeko:
- ukuxhamla;
- reflux esophagitis ;
- izilonda zohlobo loxinzelelo;
- ukuphazamiseka kwemfihlo;
- isisu sesisu;
- sesilenal ulcer;
- mastocytosis;
- Isifo se-Zollinger-Ellison.
Esi sigqirha sisetyenziselwa ukwelapha oluyinkimbinkimbi yokuphelisa i-Helicobacter pylori. Amacwecwe e-Ortanol afumene nesicelo sabo kunyango lwezilonda ezahlukeneyo zesibonda somzimba esisisifo sezifo ezivuthayo.
Thatha iziza ezi-1-2 ngosuku nge 20 mg ngaphambi kokutya. Iipsulisi zinokupheliswa ngamanzi. Ukuze kufezekiswe iinguqu ezintle ekunyangeni kwezilonda zesilonda, i-Ortanol isetyenziswe kwikhosi, ubude beentsuku eziyi-14-28. Ukuba isigulane asiva ngcono, inkqubo yeyeza kufuneka inwetshwe kwiiveki ezi-1-2.
Xa i-Helicobacter pylori ipheliswa, eli liyeza lisetyenziselwa kuphela iziyobisi ezichasayo. Ngezifo ezinjengezidumbu, i-Ortanol imele ithathwe kabini ngosuku nge 60 mg.
Kwimeko yokudlula ngaphezulu, isigulane sinokuthi:
- mbono o
- umlomo owomileyo;
- intloko;
- tachycardia;
- kulala;
- isicaphulelo.
I-antidote ekhethekileyo ayizange iphuhliswe, ngoko unyango lwe-overdose luphawu.
Ukungqinelana kwiOrtanol
Nangona unezibonakaliso zokusetyenziswa kwe-Ortanol, akufanele uwusebenzise xa u-hypersensitivity kwi-substance esebenzayo (omeprazole) okanye ezinye izixhobo zesilwanyana. Musa ukusela ezi pilisi ngexesha lokukhulelwa okanye ngexesha lokuncelisa. Ukusetyenziswa kwe-Ortanol kuvunyelwe ngaphambi kokuba uneminyaka eyi-18. Ngoqaphelisiso, le nkunkuma kufuneka isetyenziswe ngokungahambisani nentsholongwane.
Ngokusetyenziswa ngokufanayo kwe-Ortanol namanye amayeza, ukuxinwa kwe-phenytoin kunye ne-warfarin kwanda. Ngenxa yoko, isiphumo sokuvimbela isistim se-hematopoietic sinyuke kakhulu kwaye ukungalingani kokungalingani kunokwenzeka. Isiza asichaphazeli ukukwazi ukulawula iindlela ezahlukeneyo nokuqhuba iinqwelo.
Imiphumo yeOrtanol
Zonke iziphumo zecala ze-Ortanol aziba nefuthe elibi kakhulu emzimbeni wesigulane kwaye ngokuqhelekileyo banomoya omnene. Ezi ziquka:
- ukuguquka;
- isicefe
- isifo sohudo;
- intloko;
- kulala.
Kwizigulane ezinesifo sesibindi, umngcipheko wokwanda kwe-hepatitis ukwanda. Kwiimeko ezinqabileyo kakhulu, xa uthatha i-Ortanol, isigulane sinokuphazanyiswa koqhagamshelwano kunye nobudlova. Xa unyango lwangexesha elide, lunokubonakala lube nemiphumo efana nale:
- kubetha kakhulu;
- urticaria;
- angioedema ;
- umkhuhlane.