Kwizibilini kunye ne-pathogen engaziwayo okanye izifo ezixubekileyo (i-microbes, i-fungi), iziyobisi ezinomsebenzi omkhulu kakhulu kunokwenzeka. I-NO-5 yintsebenziswano echanekileyo ye-antibacterial esebenzayo kwiindawo ezincinci ezininzi ezaziwayo. Kusebenza ngokubhekiselele kwezinye iimpawu zamathambo.
5-NOC - ukwakheka
Isithako esiyinhloko sesilwanyana esikulo mbuzo ngu nitroxoline. Liyimveliso yamakhemikhali evela kwi-8-hydroxyquinoline, inqanda ukuhlanganiswa kweDNA kwiiseli ze-pathogenic kwaye inqanda ukuveliswa kwazo. Izinto ezincedisayo ezibandakanyiweyo kwi-5-NOC-tablet formulation ziquka:
- lactose monohydrate;
- calcium hydrogen phosphate;
- isitashi sommbila;
- Povidone K25;
- i-colloidal silicon dioxide;
- talc ehlambulukileyo;
- i-magnesium stearate;
- crospovidone.
Iipilisi ziveliswa kwikhokhongo ekhuselekileyo, equka izinto ezilandelayo:
- carmellose sodium;
- i-acac gum;
- i-colloidal silicon dioxide;
- Povidone K25;
- titanium dioxide;
- isitashi sommbila;
- sucrose;
- talc ehlambulukileyo;
- calcium carbonate;
- imibala yokutya - ephuzi "i-Sunset Sunset" (E110) kunye ne-quinoline (E104).
5-NOC - uphawu
Isilwayo senzelwe unyango lwezonyango eziqhelekileyo okanye ezicothayo rhoqo kwiinkqubo zokuvuthwa nokuvuthwa. Iibhulethi 5-I-NOC zisebenza ngokubhekiselele kumaqela amancinci:
- I-gram-positive aerobic kunye ne-anaerobic;
- i-gram-negative aerobic kunye ne-anaerobic;
- mycoplasma ;
- ureaplasma ;
- Trichomonas;
- I-Mycobacterium isifo sofuba;
- dermatophytes;
- ubumba isikhunta;
- umviwa;
- ii-pathogens ezibangalisa i-mycoses enzulu.
5-NOC - izibonakaliso zokusetyenziswa:
- i-cystitis;
- pyelonephritis ;
- epididymitis;
- urethritis;
- i-tumor (i-adenoma, i-carcinoma) ye-prostate;
- iprotatitis;
- iinkqubo ezivuthayo kwi-bladder okanye iphetshana eliphumayo.
Ukulungiselelwa okuchaziweyo kusetyenziswe ukuthintela usulelo kwiimeko ezinjalo:
- kwexesha elide;
- ukuxilonga;
- i-cystoscopy ;
- catheterization.
I-NO-side effects
Amachiza omzimba onamandla onokuphikisana nomzimba angakuchukumisa ukuphazamiseka komzimba kunoma yiphina inkqubo. Oku kuthetha ukuba akukho nto ikhokelela kwimiphumo emibi. Kwiimeko ezizodwa, ukulungiselela oku-5-NOC kubangela:
- tachycardia;
- ukuhlanza;
- i-anorexia;
- isicefe
- umsebenzi wesibindi;
- ukungcola;
- i-optic neuritis (kunye nokwamkelwa kwexesha elide);
- paresthesia;
- ukungabikho koqhagamshelwano;
- intloko;
- polyneuropathy;
- thrombocytopenia;
- ukwanda kwe-uric acid;
- urticaria;
- ukukhanda kwesikhumba;
- ataxia;
- ukuphazamisa umchamo ngombala obomvu ococekileyo.
I-NO-contraintations
Esi sixhobo asikhuthazwa ukunyamezela komntu nakweyiphi na isithako esibhalwe ngasentla, kubandakanywa izixhobo zeekhemikhali ezincedisayo kunye neengxenye zegobolondo. Isiyobisi se-5-NOC sinqatshelwe phantsi kwezi meko:
- khulelwa;
- cataract;
- kuncelisa;
- ukuphazanyiswa okukhulu kwesibindi okanye iimpso nge-creinine imvume engaphantsi kwe-20 ml / min (echazwe ngokungaqhelekanga, ngokuqaphela);
- uneminyaka engama-3.
Indlela yokuthabatha amacwecwe e-5-NOC?
Inxalenye yemihla ngemihla yamachiza incike kwixesha kunye nobukho bezinye izifo ezingapheliyo. Abantu abadala ngosuku badinga 400 mg yesilwanyana 5-NOC - isicelo sifaka ukuthatha le dosi, ihlukaniswe ngamaxesha amane, i-100 mg (iipilisi ezimbini) ngaphambi kokutya. Ngomlingo wesibindi oqinileyo, isabelo siphindwe kabili (800 mg). Abantwana abangaphezu kweminyaka emi-5 ubudala banqunywe i-200-400 mg yemithi rhoqo iiyure ezingama-24, kunye nabantwana abaneminyaka engama-3-5 ubudala-200 mg. Inkqubo jikelele yeyeza ayidluli kwiiveki ezi-2-4, ukuba kuyimfuneko, ziphinda.
Ngomsebenzi wokungazinzi, u-5-NOC usetyenziswe ngokuqaphela okukhulu - izibonakaliso zokusetyenziswa azifaki ezi zifo, kodwa kwiintsholongwane ezinzima, i-antibiotic inokumiselwa. Kule meko, thabatha 1 ithebhulethi eli-4 ngosuku. Kubalulekile ukubeka esweni rhoqo ukuphendulwa kweengtso kunye nesibindi kwonyango kunye nokubeka iliso kwinqanaba le-creatinine imvume.
5-NOC - isicelo se-cystitis
Umlinganiselo we-adjethi ye-antimicrobial ihambelana nomlinganiselo osemgangathweni we-400 mg nitroxoline nganye iiyure ezingama-24. 5-NOC ne-cystitis inconywa imihla ye-10-21. Ubude obuchanekileyo bonyango lubalwa yi-urologist esekelwe kwiimvavanyo zelabhoratri, ubunzima beprogram yokuvuvukala, kunye nobukho beempembelelo ezivela kwonyango. Ngamanye amaxesha kufuneka kuhanjiswe kwiinyanga ezili-1, ingakumbi ukuba usulelo luhlanganisiwe okanye lusekondari.
5-NOC nge-pyelonephritis
Ukuchazwa kwesifo kwifom elula kufuna ikhosi emfutshane ye-antibiotic therapy, 400 mg ngeentsuku ezi-2-2.5. Kwimeko engapheliyo ye-pyelonephritis ephindaphindiweyo, i-urologist inquma indlela yokuthatha i-5-NOC. Kukho izicwangciso zonyango olude eliphakathi (iintsuku ezi-2-3 ukuya kwiintsuku ezili-14) kunye neentlobo ezinokusetyenziswa kwexesha elide kwiyeza eziphantsi (100-200 mg).
Ngamanye amaxesha kuthatha i-long-reception of 5-NOC-indications for use including forms of severe pyelonephritis:
- xanthogranulomatous;
- i-purulent;
- zibalo.
5-NOC ekukhulelweni
Kulo lonke ixesha lokugaya, inkqubo ye-urinary yowesifazane iyingozi kakhulu kwaye iyancipha kwiinkqubo zokuvutha. Ngenxa yoko, oomama abanomdla bahlala benomdla kwi-5-NOC - ndingayiphuza ngexesha lokukhulelwa kunye nawaphi amanani. Le antibiotics iyachaswa kule meko, kuba inokuchaphazela kakubi ukuphuhliswa okanye ukwakheka komntwana.
5-NOC
Xa izidakamizwa ezichasayo zingasetyenziswanga okanye zibangele iimiphumo ezibi kakhulu, kuya kufuneka zikhanselwe. Indlela yodwa yokutshintsha iipilisi ze-5-NOC ngokusebenzisa izifaniso ezifanayo okanye i-generics. Kukho iingqamaniso ezimbini ezichanekileyo kwisicatshulwa esichazwe:
- I-nitroxoline (iJamani, iRashiya);
- Uroksolin (Ukraine).
Isilwanyana sokuqala siveliswa ngongxube ohlukeneyo wesithako esisebenzayo, esilungele ukwelashwa kunye namayeza aphezulu. Isisombululo sesibini kuphela kwiipilisi ezinomxholo osebenzayo wama-50 mg. Ukuba ukungahambelani ku-nitroxoline okanye i-derivatives yayo ifunyenwe, kuyimfuneko ukusebenzisa i-generic. Le michiza sele ifane neziganeko ezifanayo kunye ne-5-NOC - izibonakaliso eziphambili zokusetyenziswa, umsebenzi we-antibacterial kunye ne-antitifungal, kodwa udidi oluhlukile. Amachiza aphumelelayo anikezelwa ngendlela ye-bacteriophages:
- isifo segazi
- intes;
- ukuba;
- staphylococcal;
- Iprotheni;
- Klebsiella pneumonia;
- Pseudomonas (pseudomonas);
- kolik-proteyny;
- salmonella.
Ezinye ii-generics ezineenkcukacha ezifanayo:
- Fosmicin;
- Ureacid;
- Imvelo;
- Bernie;
- Fosmicin;
- Ngesigxina;
- Phosphoral;
- Urophosfabol;
- I-Cystoral;
- Forterase;
- Urofoscin;
- Phosphocin;
- Espa-Focine.