17-OH progesterone okanye i-17-hydroxyprogesterone yi-hormone ye-steroid eveliswa kwi-cortical substance ye-adrenal gland kwaye iyona isandulela se-hormone njenge-cortisol, i-estradiol kunye ne-testosterone. Kwakhona kuveliswa kwiingcingo zesini, i-follicle evuthiweyo, umzimba ophuzi kunye ne-placenta kwaye phantsi kwefuthe le-enzyme 17-20 lyase iyaba ngama-hormone esondo. Emva koko, siza kuqwalasela nayiphi indima ephambili ye-progesterone emzimbeni womfazi ongeyena okhulelwe kunye nokukhulelwa kunye neempawu zokunyuka nokungazinzi.
Izinto eziphilayo ze-bi-hormone 17-oh progesterone
Umgangatho ngamnye womntu we-17-OH progesterone uguquka kwiiyure ezingama-24. Ngoko ke, ubuncinci bayo buncinci bubonakala kwiiyure zasekuseni, kwaye ubuncinci - ngobusuku. I-progesterone ye-17-OH yabasetyhini iyahluka ngokuxhomekeka kwisigaba somjikelezo wesini. Ukwanda kwenyuka kwinqanaba le hormone kuphawulwe ngokuhlwa kwe-ovulation (phambi kokunyuka okuphezulu kwimilamoni ye-luteinizing). I-progesterone ye-17-OH kwisigaba sokulandelela isinciphisa ngokukhawuleza, ifikelele kwisigaba esincinane kwisigaba se-ovulation.
Ngoku qwalasela ixabiso eliqhelekileyo le-progesterone ye-17-OH, kuxhomekeke kwisigaba somjikelezo wesini:
- kwisigaba esilandelayo - 0.99-11.51 i-nmol / l;
- kwisigaba sokulandelana - i-1,24-8,24 i-nmol / l;
- kwisigaba se-ovulation - 0,91-4,24 i-nmol / l.
I-progesterone ye-17-OH ekukhuliseni iyakwanda, ifikelela kwiimpawu eziphezulu kwiiveki zangoku nje. Ngexesha lokukhulelwa, i-placenta iphinda iphendule kwi-hormone ye-steroid. Cinga ixabiso elivumelekileyo le-17-OH progesterone ngexesha lokukhulelwa:
- kwi-trimester yokuqala-3,55-17,03 i-nmol / l;
- kwi-trimester yesibini - 3,55-20 i-nmol / l;
- kwikota yesithathu - 3.75-33.33 i-nmol / l.
Kwi-premenopausal nangethuba lokuphuma kwesisu, izinga le- hormone 17-OH progesterone linciphisa kakhulu kwaye lifikelela kwi-0.39-1.55 i-nmol / l.
Tshintsha kwinqanaba le-17-OH progesterone - ukuxilongwa kunye neempawu
Inqanaba elaneleyo le-17-OH progesterone egazini lidla ngokuba yimbangela ye-adrenal hypoplasia kwaye inokudibaniswa nokuveliswa kwemveliso yamanye amahomoni. Kwizonyango, iyakwazi ukuzibonakalisa ngesimo sesifo se-Addison, kwaye abafana bangaphantsi kokuphuhlisa i-genitalia yangaphandle.
Ukwanda kwe-17-OH progesterone ingaqhelekanga kuphela ekukhulelweni, kwezinye iimeko kubonisa i-pathology. Ngoko-ke, i-progesterone ephezulu ye-17-OH ingabonakalisa uphawu lwezitho zomzimba, i-ovaries (iifomu ezinobungozi kunye ne-polycystosis) kunye neengxaki ze-genetic ze-correnx ye-adrenal.
Kwizonyango, ukwanda kweprogesterone ye-17-OH ingabonakaliswa:
- ukuphulwa komjikelezo wesini;
- ukungabikho;
- ukukhipha isisu;
- ukuzalwa komntwana okanye ukufa kwasekusaneni;
- ukwanda kweprogesterone 17-OH ingabonakaliswa ngenduna (iimpumpi);
- Ukuba i-progesterone ye-17-OH iphakanyisiwe, i-testosterone nayo inokuphakanyiswa. Oku kungabonakaliswa ngohlobo lokukhula kweenwele ebusweni nasemzimbeni (uhlobo lweenwele zesilisa).
I-progesterone ye-17-OH inganqunywa ngokuhlola i-serum
Ngaloo ndlela, sihlolisise indima yezinto eziphilayo kwi-hormone 17-OH progesterone kunye nemilinganiselo yayo evumelekileyo kwabasetyhini. Ukuncipha kwinqanaba le hormone kunokuqhelekileyo kube kuphela ngexesha lokutshatyalaliswa kwexesha, kwaye ukwanda kwawo kuthathwa njengento eqhelekileyo phakathi nokukhulelwa. Utshintsho kwinqanaba le-17-OH progesterone kwezinye iimeko lingaba linye yeempawu ze-adrenal and ovarian disease, ekhokelela kwi-hyperandrogenism, ukungabikho komntwana okanye ukukhupha isisu.